2010年8月30日星期一

Zebra finch genome

          Zebra finch genome


       The zebra finch can communicate through learned vocalizations. It is therefore an important model for human neuroscience. Now, genome analysis is revealing that vocalization engages gene-regulatory networks in the zebra finch brain, altering the expression of long non-coding RNAs, microRNAs and transcription factors. In addition,Sexy silk dresses, comparative approaches are providing evidence of the rapid molecular evolution of genes regulated during song experience. This web focus celebrates the publication of the zebra finch genome, and showcases recent papers on vocal learning and memory published in Nature or simultaneously in Genome Research and BioMed Central journals.

target genes by a small viral protein

 


         target genes by a small viral protein


      Adenovirus E1B-55k targets transcription factor p53 for degradation and is thought to be critical for p53 inactivation during adenovirus replication. Indeed, mutant viruses lacking E1B-55k have been tested as viral cancer therapies selective for p53-positive tumours. These authors find another adenoviral protein,silk pajamas, E4-ORF3, to inactivate p53 independently of E1B-55k by means of a chromatin-silencing mechanism that prevents access of p53 to its DNA target sites.


Conrado Soria, Fanny E. Estermann, Kristen C. Espantman & Clodagh C. O’Shea

Malaria 2010 update

        Malaria 2010 update,Sexy silk pajamas


        Despite increasing research efforts, malaria remains a significant cause of human mortality. The discovery of new drug and vaccine leads, the implementation of effective control measures in light of a changing world and an understanding of the mechanisms underlying human-parasite and vector-parasite interactions are all required to get a step closer to the ultimate goal of eradicating this disease. In all of these areas, the past year has produced some very interesting new insights that we are proud to present in this focus.

Disasters widen the gap between rich and poor

       Disasters widen the gap between rich and poor


     New Orleans's recovery five years on from Katrina is a harbinger of how climate change will drive a thicker wedge between the haves and the have-nots, says John Mutter in an Opinion piece in this week's Nature. As the fifth anniversary of Hurricane Katrina approaches, recovery in New Orleans is still patchy. Hurricane Katrina is a powerful example of things to come. For more,Silk Queen Quilt Cover, listen to this week's Nature Podcast.